The Use of the Proteolytic Enzyme Brinase to Produce Autocytotoxicity in Patients with Acute Leukemia and Its Possible Role in Immunotherapy1
نویسندگان
چکیده
Daily infusion of brinase (Protease 1 of Aspergillus oryzae) for 10 to 30 days in six patients (three children, three adults) with acute leukemia resulted in the production of complement-dependent autocytotoxicity against leukemic cells and lymphocytes and, in some instances, against platelets. This appeared to be due to the production of autoantibody, but its nature remains to be elucidated. The autocytotoxicity can be demonstrated in vivo by blood transfusion from a healthy donor or in vitro at 37° by Terasaki's
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